Senjutsu Choukoukaku OrionOrion - Shirow, Masamune

The main plot revolves around the Yamata Empire's plan to destroy all the galaxy's negative karma using a massive technological reactor called the Nāga Generator. Unfortunately, negative karma cannot simply be destroyed, it must be atoned for. However the leader of the powerful mystic Buddhist Fuze Clan plans to stop the destruction of the negative karma which will end up creating the nine-headed Nāga and destroy the world if not the whole universe. To help in stopping the creation of the Nāga, the clan summons a Shinto god known as Susano, the Warrior God of Destruction. The powerful, arrogant, and homicidal god faces challenges. These include the Empire and the clan leader's own daughter, the bratty sorceress Seska, who is possessed by the power of the negative Karma and a powerful magic formula.

(Source: Wikipedia)

Senjutsu Choukoukaku Orion was published in English as Orion in six issues by Dark Horse Comics from September 1992 to July 1993.