Kekkai Sensen's pilot serialization ran in Jump SQ from the February to April 2009 issues under the title Kekkai Sensen: Mafuugai Kessha (血界戦線 ―魔封街結社―), which was later collected in the first volume. The official serialization started next year in Jump SQ.19 Vol.1 (2010/5), and continued until Vol.18, when the magazine was discontinued. The manga's second season, Kekkai Sensen: Back 2 Back, started the same year in the new quarterly magazine Jump SQ.Crown.
The series was published in English as Blood Blockade Battlefront by Dark Horse Manga from September 14, 2011 to August 7, 2018.